Methyl Sulphonyl Methane better known as MSM, is a naturally occurring Sulphur compound with well-known antioxidant properties.
- Increases Glutathione levels.
Epithelialization (Wound Healing)
- Induces Wound Healing
- Protects against acute renal failure.
- Helps maintain normal Keratin levels.
Disease / Symptom Treatment
Repetitive Stress Injuries
Title: The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
Author(s): Shaza Anwar Al laham
Institution(s): Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damascus University, Syria
Publication: Brazilian Journal of Pharmaceutical Sciences
Date: June 07, 2018
Abstract: The present study was performed to explore the curative effect of Methylsulfonylmethane (MSM) in an experimental model of myoglobinuric acute renal failure (ARF). In this experimental model, Rats were injected with 50% glycerol (10 mL/kg, im) followed by an hour later and daily in the next six days by MSM (400 mg/kg) or saline. Kidney’s function (urea and creatinine), and reduced glutathione were analyzed. A renal failure produced by glycerol injection, with a significant increase of blood urea and serum creatinine was observed. Rats that received MSM in addition to glycerol had significantly lower blood urea and serum creatinine levels compared to those receiving glycerol alone. However, glutathione has markedly increased after MSM treatment. The effect is probably due to the antioxidant activity of MSM. This may provide therapeutic opportunities for treating humans, myoglobinuric ARF.
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