Cumin (Cuminum cyminum) is a flowering plant in the parsley family which produces a fruit that contains aromatic seeds which are dried and used as a spice, they are usually ground into a powder and used in curry.
- Chemopreventive: C. cyminum fruits reduce the risk of, or delay the development or recurrence of, cancer.
- Antioxidant: Cuminum cyminum L. essential oil supplementation can improve some antioxidative indices in the body.
- Antiinflammatory: Cuminum cyminum L. essential oil supplementation increased superoxide dismutase (a very important antioxidant defense in the body) and total antioxidant capacity while decreasing malondialdehyde (a highly reactive compound that is a marker for oxidative stress).
- Weight Loss:
- Lipid Profile: Cumin has been shown to have a beneficial effect on lipid profile.
Disease / Symptom Treatment
- Fungal Pathogens:
- Obesity: Cumin powder (along with a weight reduction diet) showed improvement in anthropometric and biochemical parameters in overweight/obese women.
- Cumin powder significantly reduced weight, BMI, waist circumference, fat mass and its percentage.
- Hypercholesterolemia: Cumin powder reduced serum levels of fasting cholesterol, triglyceride, and LDL and increased HDL.
- Breast Cancer: Flavonoids especially luteolin-7-O-glucoside play a significant role in cytotoxic effect of C. cyminum fruits and can be introduced as candidate for chemopreventive and chemotherapeutic drugs.
Study Type: Human Study: In Vitro
Title: Cuminum cyminum fruits as source of luteolin-7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines
Author(s): Saied Goodarzi, Mir Javad Tabatabaei, Razieh Mohammad Jafari, Farzaneh Shemirani, Saeed Tavakoli, Mansur Mofasseri, and Zahra Tofighi
Institution(s): Mansur Mofasseri School of Chemistry, University College of Science, University of Tehran, Tehran, Iran; Mir Javad Tabatabaei Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
Publication: Natural Product Research
Date: December 2018
Abstract: Cuminum cyminum is famous for its spicy fruits used for culinary and therapeutic properties worldwide. Brine shrimp test was performed for detecting cytotoxic fractions and subfractions. Ethyl acetate (EA) and hexane (HE) fractions demonstrated LC50 of 52.40 and 60.77 µg/ml against Artemia salina while other fractions showed no toxicity (LC50> 500 µg/ml). Bioguided elucidation of EA and HE fractions were carried out and cytotoxicity of pure compounds were investigated against breast cancer cell lines (MCF-7 and MDA-MB-231) and normal cell line (NIH/3T3) by MTT assay. Four flavone structures as luteolin, apigenin, luteolin-7-O-glucoside and apigenin-7-O-glucoside from EA and cuminoid A from HE were purified and identified. Luteolin-7-O-glucoside demonstrated potent anticancer activities against MCF-7 cell line (IC50 of 3.98 µg/ml) with selectivity index of 8.0. In conclusion, flavonoids especially luteolin-7-O-glucoside play a significant role in cytotoxic effect of C. cyminum fruits and can be introduced as candidate for chemopreventive and chemotherapeutic drugs.
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Study Type: Human Study: In Vivo
Title: Effect of cumin powder on body composition and lipid profile in overweight and obese women
Author(s): Roghayeh Zare, Fatemeh Heshmati, Hossein Fallahzadeh, Azadeh Nadjarzadeh
Institution(s): Nutrition and Food Security Research Centre, Shahid Sadoughi University of Medical Sciences, Iran; Department of Nutrition, Shahid Sadoughi University of Medical Sciences, Iran; Department of Epidemiology and Biostatistics, Shahid Sadoughi University of Medical Sciences, Iran
Publication: Complementary Therapies in Clinical Practice
Date: October 2014
Abstract: Introduction: This study aimed to determine the effect of cumin powder on body composition and lipid profile in overweight and obese women. Materials & methods: In this randomized clinical trial, 88 overweight/obese women were randomly assigned into two groups. The experimental group was asked to have 3 g/d cumin powder with yogurt at two meals for 3 months. The same amount of yogurt minus cumin powder was prescribed for the control group. All patients received nutrition counseling for weight loss in a similar manner. Anthropometric and biochemical parameters were determined before and after the intervention. Results: Cumin powder reduced serum levels of fasting cholesterol, triglyceride, and LDL and increased HDL. Weight, BMI, waist circumference, fat mass and its percentage significantly reduced. It has no effect on FBS and fat-free mass. Conclusion: Cumin powder in a weight reduction diet showed improvement in anthropometric and biochemical parameters in overweight/obese women.
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