Last edited 09/28/2019 08:33:05 PM by Anthony Russano (email@example.com)
- Broccoli sprout juice contains sulforaphanyl-amine.
- Broccoli sprouts are naturally enriched in glucoraphanin,the biological precursor to the anticancer compound sulforaphane.
- Vitamin C
Broccoli is effective in preventing inflammatory responses.
(prevent damage to the liver) Dietary broccoli exerts a substantial protective effect on the liver.
Broccoli consumption helps reduce plasma alanine aminotransferase concentrations in the liver. This is an enzyme found in the liver, normally at low levels. Increased levels of this enzyme are associated with liver damage and its level is used to screen for and/or monitor liver disease.
Sulforaphane (an active compound in broccoli) protects against liver damage, indicating its potential to treat liver diseases.
Disease / Symptom Treatment
Cancer Treatment / Prevention
Medicinal vegetables such as broccoli and their derivative phyto-compounds are being increasingly recognized as useful complementary treatments for cancer. Indole-3-carbinol (I3C), a natural phytochemical found in cruciferous vegetables (i.e. broccoli, cabbage or cauliflower), is considered a potential anticancer agent that prevents the development of certain types of tumors by activating tumor suppressor genes, genes involved in apoptosis and detoxification. I3C suppresses cell proliferation and induces apoptosis.
- Broccoli is effective in preventing carcinogenesis.
Hepatocellular carcinoma (HCC)
(a form of liver cancer) Long-term consumption of whole broccoli countered development of hepatic tumorigenesis.
Broccoli is effective in preventing diabetes.
Non-Alcoholic Fatty Liver Disease (NAFLD)
(hepatic lipidosis) Long-term consumption of whole broccoli countered NAFLD development enhanced by a Western diet.
- Dietary consumption of freeze-dried broccoli was shown to lower the level of hepatic triglycerides.
- Dietary broccoli decreased relative liver mass.
Title: Glucoraphanin and sulforaphane evolution during juice preparation from broccoli sprouts
Author(s): Cristiano Bello, Mariateresa Maldini, Simona Baima, Cristina Scaccini, Fausta Natella
Institution(s): Food and Nutrition Research Centre, Via Ardeatina 546, 00178 Roma, Italy
Publication: Food Chemistry
Date: 19 June 2018
Abstract: Broccoli sprouts are considered functional food as they are naturally enriched in glucoraphanin (GR) that is the biological precursor of the anticancer compound sulforaphane (SFN). Due to its health promoting value, also broccoli sprout juice is becoming very popular. The present study aimed to quantitatively assess the conversion of GR to its hydrolysis products, SFN and SFN-nitrile, during the juice preparation process. We demonstrated that SFN plus SFN-nitrile yield from glucoraphanin is quite low (≈25%) and that some SFN is lost during the juice preparation partially due to the spontaneous conversion to sulforaphane-amine or conjugation to GSH and proteins naturally present in the juice. Our results demonstrate that the detection of the sole SFN free form does not provide reliable information about the real concentration of this functional compound in the juice.
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Study Type: Animal Study
Title: Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways
Author(s): Changhun Lee, Sumin Yang, Bong-Seon Lee, So Yeon Jeong, Kyung-Min Kim, Sae-Kwang Ku
Institution(s): Changhun Lee College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea
Publication: Journal of Asian Natural Products Research
Date: March 2019
Abstract: The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases.
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Study Type: Animal Study
Title: Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet
Author(s): Yung-Ju Chen, Matthew A Wallig, and Elizabeth H Jeffery
Institution(s): Departments of Food Science and Human Nutrition and Pathobiology, University of Illinois, Urbana, IL; This work was supported by funding from National Cancer Institute grant no. 5RO3CA162539-02.
Publication: The Journal of Nutrition
Date: Feb 2016
Abstract: Background: The high-fat and high-sugar Westernized diet that is popular worldwide is associated with increased body fat accumulation, which has been related to the development of nonalcoholic fatty liver disease (NAFLD). Without treatment, NAFLD may progress to hepatocellular carcinoma (HCC), a cancer with a high mortality rate. The consumption of broccoli in the United States has greatly increased in the last 2 decades. Epidemiologic studies show that incorporating brassica vegetables into the daily diet lowers the risk of several cancers, although, to our knowledge, this is the first study to evaluate HCC prevention through dietary broccoli. Objective: We aimed to determine the impact of dietary broccoli on hepatic lipid metabolism and the progression of NAFLD to HCC. Our hypothesis was that broccoli decreases both hepatic lipidosis and the development of HCC in a mouse model of Western diet–enhanced liver cancer. Methods: Adult 5-wk-old male B6C3F1 mice received a control diet (AIN-93M) or a Western diet (high in lard and sucrose, 19% and 31%, wt:wt, respectively), with or without freeze-dried broccoli (10%, wt:wt). Starting the following week, mice were treated once per week with diethylnitrosamine (DEN; 45 mg/kg body weight intraperitoneally at ages 6, 7, 8, 10, 11, and 12 wk). Hepatic gene expression, lipidosis, and tumor outcomes were analyzed 6 mo later, when mice were 9 mo old. Results: Mice receiving broccoli exhibited lower hepatic triglycerides (P < 0.001) and NAFLD scores (P < 0.0001), decreased plasma alanine aminotransferase (P < 0.0001), suppressed activation of hepatic CD68+ macrophages (P < 0.0001), and slowed initiation and progression of hepatic neoplasm. Hepatic Cd36 was downregulated by broccoli feeding (P = 0.006), whereas microsomal triglyceride transfer protein was upregulated (P = 0.045), supporting the finding that dietary broccoli decreased hepatic triglycerides. Conclusion: Long-term consumption of whole broccoli countered both NAFLD development enhanced by a Western diet and hepatic tumorigenesis induced by DEN in male B6C3F1 mice.
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Title: Phytotherapy of Prostate Cancer: How far are we?
Author(s): Guy-Armel Bounda
Publication: Clinical Oncology: Case Reports
Abstract: Prostate cancer (PCa) is the second most diagnosed cancer in men, principally affecting men over 50 years old, and is the fifth leading cause of cancer-related deaths in men worldwide. In recent years, the use of complementary and alternative medicine (CAM) has increased, especially among oncology patients. Treatment options are limited in androgen-independent prostate cancer. To reduce this tremendous health burden, new approaches have been directed toward extremes of the disease spectrum centering on strategies for prostate cancer prevention and for treating advanced androgen-independent cancers. Medicinal herbs and their derivative phytocompounds are being increasingly recognized as useful complementary treatments for cancer. Great number of clinical studies have reported the beneficial effects of herbal medicines on the survival, immune modulation, and quality of life (QOL) of cancer patients, when these herbal medicines are used in combination with conventional therapeutics. Although, tremendous efforts have been done in phytomedicine and phytotherapy, we still have a long way to go.